Breakthrough from the University of Trieste Enhances Gene Therapy for Cardiovascular Diseases

The research group led by Serena Zacchigna at the University of Trieste has found a new way of improving gene therapy for cardiovascular diseases by enhancing the efficiency of gene transfer to cardiac endothelial cells. They found that endothelial to mesenchymal transition (EndMT), which happens spontaneously in many pathological conditions, significantly boosts AAV transduction. These results, published in November 2024 in Molecular Therapy, offers new opportunities to drive therapeutic angiogenesis in the heart and opens new avenues of investigations to improve our current capacity to deliver therapeutic genes to diseases tissues.

Link to the publication: https://pmc.ncbi.nlm.nih.gov/articles/PMC11573677/?utm_source=chatgpt.com